6.20.2006

What are the side effects of your media?

Just a brief mention of an interesting paper recently published in Neuromuscular Disorders. In this paper by Ian Holt in the laboratory of Glen Morris they explore the defects in nuclear morphology associated with lamin mutations resulting in emery dreifuss muscular dystrophy. The take home message is that nuclear morphology is more pronounced in growth media that allow for more rapid cell proliferation. This is clearly something to keep in mind for anyone studying the nucleus and probably macromolecular cellular assembly using standard tissue culture techniques.

Lamin A/C assembly defects in Emery–Dreifuss muscular dystrophy can be regulated by culture medium composition
Ian Holt, Nguyen thi Man, Manfred Wehnert , Glenn E. Morris


http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T9T-4JXPS4K-3-3&_cdi=5123&_user=18704&_orig=search&_coverDate=06%2F30%2F2006&_qd=1&_sk=999839993&view=c&wchp=dGLbVtb-zSkzV&md5=dcf45a449ff42ce99e6813cd6e182e79&ie=/sdarticle.pdf

0 Comments:

Post a Comment

Links to this post:

Create a Link

<< Home